Prostate cancer how fast does it spread
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Print This Page Click to Print. Bryant Mandap. Don I. Bill M. Roger Magyar. Bruce Rocheleau. Free Healthbeat Signup Get the latest in health news delivered to your inbox! Sign Up. Metastatic castration-resistant prostate cancer is when cancer has spread past the prostate into the body and it is able to grow and spread even after treatments were used to lower testosterone levels.
This is disease progression despite medical or surgical castration. Men with advanced prostate cancer may or may not have any signs of sickness. Symptoms depend on the size of new growth and where the cancer has spread in the body. With advanced disease, mainly if you have not had treatment to the prostate itself, you may have problems passing urine or see blood in your urine. Some men may feel tired, weak or lose weight. When prostate cancer spreads to bones, you may have bone pain. Tell your doctor and nurse about any pain or other symptoms you feel.
There are treatments that can help. Advanced cancer may be found before, at the same time or later than the main tumor. Most men diagnosed with advanced prostate cancer have had biopsy and treatment in the past.
When a new tumor is found in someone who has been treated for cancer in the past, usually cancer has spread. Even if you have already been diagnosed with prostate cancer, your health care provider may want to observe changes over time. The following tests are used to diagnose and track prostate cancer:.
Only the prostate and prostate cancers make PSA. It is used to stage cancer, plan treatment and track how well treatment is going. A rapid rise in PSA may be a sign something is wrong.
In addition, your doctor may want to test the level of testosterone in your blood. Advanced cancer may be found before, at the same time, or later than the main tumor. This test is also used to screen for and stage cancer, or track how well treatment is going.
During this test, the doctor feels for an abnormal shape, consistency, nodularity or thickness to the gland. For this exam, the health care provider puts a lubricated gloved finger into the rectum. Men diagnosed with advanced prostate cancer from the beginning may start with a prostate biopsy. It is also used to grade and stage the cancer. Most men diagnosed with advanced prostate cancer have had a prostate biopsy in the past. When a new tumor is found in someone who has been treated before, it is usually cancer that has spread.
A biopsy is a tissue sample taken from your prostate or other organs to look for cancer cells. There are many approaches to prostate biopsies. These can be done through a probe placed in the rectum, through the skin of the perineum already between the scrotum and rectum and may use a specialized imaging device, such as MRI.
The biopsy removes small pieces of tissue for review under a microscope. The biopsy takes 10 to 20 minutes. A pathologist a doctor who classifies disease looks for cancer cells within the samples.
If cancer is seen, the pathologist will "grade" the tumor. Prostate cancer is grouped into four stages. The stages are defined by how much and how quickly the cancer cells are growing. If a biopsy finds cancer, the pathologist gives it a grade. The most common grading system is called the Gleason grading system. The Gleason score is a measure of how quickly the cancer cells can grow and affect other tissue.
Biopsy samples are taken from the prostate and given a Gleason Grade by a pathologist. Lower grades are given to samples with small, closely packed cells.
Higher grades are given to samples with more spread out cells. The Gleason Score is set by adding together the two most common grades found in a biopsy sample. The Gleason score will help your doctor understand if the cancer is as a low-, intermediate- or high-risk disease. The risk assessment is the risk of recurrence after treatment. Generally, Gleason scores of 6 are treated as low risk cancers. There are two types of these scores.
Gleason scores of 8 and above are treated as high-risk cancers. Some of these high-risk tumors may have already spread by the time they are found. See More See Less. The T, N, M score is a measure of how far the prostate cancer has spread in the body.
The T tumor score rates the size and extent of the original tumor. The N nodes score rates whether the cancer has spread into nearby lymph nodes. The M metastasis score rates whether the cancer has spread to distant sites. Tumors found only in the prostate are more successfully treated than those that have metastasized spread outside the prostate.
Tumors that have metastasized are incurable and require drug based therapies to treat the whole body. The goal of advanced prostate cancer treatment is to shrink or control tumor growth and control symptoms.
There are many treatment choices for advanced prostate cancer. Which treatment to use, and when, will depend on discussions with your doctor. It is best to talk to your doctor about how to handle side effects before you choose a plan. Hormone therapy is a treatment that lowers a man's testosterone, or hormone, levels.
This therapy is also called ADT. Testosterone, an important male sex hormone, is the main fuel for prostate cancer cells, so reducing its levels may slow the growth of those cells. Hormone therapy may help slow prostate cancer growth in men when prostate cancer has metastasized spread away from the prostate or returned after other treatments. Some treatments may be used to shrink or control a local tumor that has not spread.
There are several types of hormone therapy for prostate cancer treatment, including medications and surgery. Your doctor may prescribe a variety of therapies over time. Surgery to remove the testicles for hormone therapy is called orchiectomy or castration. When the testicles are removed, it stops the body from making the hormones that fuel prostate cancer. It is rarely used as a treatment choice in the United States. Men who choose this therapy want a one-time surgical treatment.
They must be willing to have their testicles permanently removed and must be healthy enough to have surgery. This surgery allows the patient to go home the same day. The surgeon makes a small cut in the scrotum sac that holds the testicles. The testicles are detached from blood vessels and removed. The vas deferens tube that carries sperm to the prostate before ejaculation is detached. Then the sac is sewn up. There are multiple benefits to undergoing orchiectomy to treat advanced prostate cancer.
It is not expensive. It is simple and has few risks. It only needs to be performed once. It is effective right away. Testosterone levels drop dramatically. Talk to your doctor about what you can expect from your hormone treatment. Chemo is the use of drugs to fight cancer.
The drugs may be given into a vein or taken as pills. These drugs go into the blood and spread through the body. Chemo is given in cycles or rounds. Each round of treatment is followed by a break. Chemo may be used if the cancer has spread outside the prostate gland. Chemo can make you feel very tired, sick to your stomach, and cause your hair to fall out.
But these problems go away after chemo treatment ends. There are ways to treat most chemo side effects. If you have side effects, talk to your doctor so they can help. If prostate cancer spreads to other parts of the body, it almost always goes to the bones first. These areas of cancer spread can cause pain and weak bones that might break.
Medicines that can help strengthen the bones and lower the chance of fracture are bisphosphonates and denosumab. Sometimes, radiation, radiopharmaceuticals, or pain medicines are given for pain control.
A serious side effect of bisphosphonates and denosumab is damage to the jaw, also called osteonecrosis of the jaw ONJ.
Most people will need to get approval from their dentist before starting one of these drugs. Clinical trials are research studies that test new drugs or other treatments in people. They commonly compare standard treatments with others that may be better. If you would like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials. See Clinical Trials to learn more.
Clinical trials are one way to get the newest cancer treatment. They are the best way for doctors to find better ways to treat cancer. And if you do sign up for a clinical trial, you can always stop at any time.
When you have cancer you might hear about other ways to treat the cancer or treat your symptoms. These may not always be standard medical treatments.
These treatments may be vitamins, herbs, special diets, and other things. You may wonder about these treatments. Some of these are known to help, but many have not been tested. This is different from primary bone cancer, where the cancer starts in the bones. It can be influenced by factors like age and how much the cancer has spread. People with more than one site of cancer spread have a lower life expectancy. Findings from one study estimated that in those with prostate cancer that spreads to the bones:.
Early detection can catch prostate cancer even before there are any symptoms. Some types of prostate cancer grow very slowly.
There are four main stages of prostate cancer. Within each stage, the cancer is graded based on factors like the size of tumor, prostate-specific antigen PSA level, and other clinical signs. Newer lab tests look at the genes inside cancer cells. This can provide more information on how quickly the prostate cancer may progress. During the biopsy to diagnose prostate cancer, the cells are closely examined. The more abnormal cells that are in the biopsy sample, the higher the Gleason score and grade group.
The prognosis for prostate cancer with bone metastases depends on several factors.
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